國家衛生研究院 NHRI:Item 3990099045/5649
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    題名: Toxicological analysis to determine the TDI of melamine in food
    作者: Hsieh, DPH;Chiang, CF;Chiang, PH;Wen, CP
    貢獻者: Division of Health Services and Preventive Medicine
    摘要: Abstract: Intensified food safety concern over melamine has prompted national authorities to assess its tolerable daily intake (TDI) for protection of general population including young children. TDI is calculated by dividing a no-observed-adverse-effect level (NOAEL) by a safety factor (SF). Based on appropriate choices of values, the U.S. Food and Drug Administration determined two TDI values in the unit of mg per kg body weight per day as first 0.63 and then 0.063, while the World Health Organization, 0.5 and then 0.2, as a result of increasing the SF values in calculation. We used the benchmark dose analysis method on the same set of toxicity data to determine an appropriate NOAEL, and then used an SF of 1000 to obtain a TDI of 0.0081. Arguments in support of this considerably lower TDI value were provided to alert the international community
    日期: 2009-12
    關聯: Society For Risk Analysis Annual Meeting 2009. 2009 December 6-9:82.
    Link to: http://birenheide.com/sra/2009AM/program/singlesession.php3?sessid=P&order=82#82
    顯示於類別:[江博煌] 會議論文/會議摘要
    [溫啟邦(2001-2010)] 會議論文/會議摘要

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