Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/5702
|
| Title: | IL-10 promoter genetic polymorphisms and risk of Kawasaki disease in Taiwan |
| Authors: | Hsieh, KS;Lai, TJ;Hwang, YT;Lin, MW;Weng, KP;Chiu, YT;Ho, TY;Chen, CS;Shiue, YL;Hsiao, M;Tsai, SF;Ger, LP |
| Contributors: | Institute of Molecular and Genomic Medicine |
| Abstract: | Kawasaki disease (KD) is the most common cause of pediatric acquired heart disease. KD patients have spontaneously high plasma/serum levels of IL-10 during the acute phase. Therefore, two independent studies were carried out to investigate the association between genetic variants in IL-10 promoter (-1082,-819, and-592) and risk of KD. A total of 134 trios were included for the family-based association study. A significantly preferential transmission of the C allele at loci-819 T > C and-592 A > C for KD cases was observed (Ppermutation = 0.029 and Ppermutation = 0.034, respectively). There was a significant increase in the transmission of haplotype CC (p = 0.016) at the above two loci (OR, 1.632; 95% CI, 1.090-2.443; P permutation = 0.019). We also carried out a follow-up case-control study that included 146 KD cases and 315 unrelated healthy children. The haplotype CC (-819,-592) showed an increased risk of KD (but statistically non-significant; OR, 1.332; 95% CI, 0.987-1.797; p = 0.061). In diplotype analysis, a trend was found between number of CC haplotype and risk of KD (but non-significant, p =0.061). In conclusion, CC genotype and CC/CC diplotype at IL-10-819T > C and-592A > C were significantly associated with risk of KD in case-parent trio study, which were replicated partially in our follow-up case-control study. |
| Date: | 2011-04 |
| Relation: | Disease Markers. 2011 Apr;30(1):51-59. |
| Link to: | http://dx.doi.org/10.3233/dma-2011-0765 |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000290961500006 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79955115477 |
| Appears in Collections: | [蔡世峯] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| SCP79955115477.pdf | | 852Kb | Adobe PDF | 269 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
