國家衛生研究院 NHRI:Item 3990099045/5721
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    题名: Rapid and sensitive detection of cancer cells by coupling with quantum dots and immunomagnetic separation at low concentrations
    作者: Hsieh, YH;Lai, LJ;Liu, SJ;Liang, KS
    贡献者: Division of Vaccine Research and Development
    摘要: This work presents a rapid and sensitive method for detecting cancer cells at low concentration. In this method, two biomarkers of T-help cancer cells are detected simultaneously. One biomarker is conjugated with magnetic beads to separate T-help cell from the mixed cells and the other biomarker, associated with quantum dots, is used to detect fluorescence. The specific T-help cells can be quantified using the relationship between the QD fluorescence intensity and the cell frequency following magnetic separation. The intensity of fluorescence increases linearly with the frequency of T-help cells from 10-7 to 10-3, and neither B cells nor red blood cells interfere with the detection of T-help cells. Moreover, the total detection time is under 15 min, even though the frequency of specific T-help cells is as low as 5 ? 10-7. The numerous advantages of detecting specific cells at low concentration using the presented method include ease of preparation, low cost, fast detection, and high sensitivity.
    日期: 2011-06-15
    關聯: Biosensors and Bioelectronics. 2011 Jun 15;26(10):4249-4252.
    Link to: http://dx.doi.org/10.1016/j.bios.2011.04.023
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0956-5663&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000291904000045
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79956355430
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