國家衛生研究院 NHRI:Item 3990099045/5738
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5738


    Title: The quantitative detection of aripiprazole and its main metabolite by using capillary-electrophoresis
    Authors: Tsai, CJ;Yu, YH;Chiu, HJ;Loh, EW;Wang, JT;Chan, CH;Lan, TH
    Contributors: Division of Mental Health and Addiction Medicine
    Abstract: Background:We aimed to establish a feasible and reliable method to measure the level of aripiprazole and its main metabolite, dehydroaripiprazole, using a capillary-electrophoresis (CE) machine. Methods:Two blood samples were obtained from psychiatric patients hospitalized in Yu-Li Hospital who had been treated with aripiprazole for more than 4 weeks, at least 10 mg/d. Conditions for voltage, temperature and buffer concentration was optimized on a CE machine. Results:The most optimal conditions for CE were 80 mM 2–3% DMSO-phosphate as a buffer under pH = 3.0, 15 KV, 20°C and a detection wavelength of 214 nm. The linear ranges of aripiprazole and dehydroaripiprazole concentration were from 0.5 to 50 ng/mL. Conclusion:CE method is a feasible method to measure aripiprazole level with relatively low price compared with other analytical techniques for clinical use.
    Date: 2011-06
    Relation: Journal of the Chinese Medical Association. 2011 Jun;74(6):267-271.
    Link to: http://dx.doi.org/10.1016/j.jcma.2011.04.006
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1726-4901&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000292342400006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79957446835
    Appears in Collections:[El-Wui Loh(2004-2012)] Periodical Articles

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