國家衛生研究院 NHRI:Item 3990099045/6380

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Title:	In vitro feasibility study of the use of a magnetic electrospun chitosan nanofiber composite for hyperthermia treatment of tumor cells
Authors:	Lin, TC;Lin, FH;Lin, JC
Contributors:	Division of Medical Engineering Research
Abstract:	Hyperthermia has been reported to be an effective cancer treatment modality, as tumor cells are moretemperature-sensitive than their normal counterparts. Since the ambient temperature can be increasedby placing magnetic nanoparticles in an alternating magnetic ﬁeld it has become of interest to incorpo-rate these magnetic nanoparticles into biodegradable nanoﬁbers for possible endoscopic hyperthermiatreatment of malignant tumors. In this preliminary investigation we have explored various characteris-tics of biodegradable electrospun chitosan nanoﬁbers containing magnetic nanoparticles prepared by dif-ferent methods. These methods included: (1) E-CHS-Fe 3 O 4 , with electrospun chitosan nanoﬁbers directlyimmersed in a magnetic nanoparticle solution; (2) E-CHS-Fe2+, with the electrospun chitosan nanoﬁbersinitially immersed in Fe+2/Fe+3solution, followed by chemical co-precipitation of the magnetic nanopar-ticles. The morphology and crystalline phase of the magnetic electrospun nanoﬁber matrices were deter-mined by scanning electron microscopy, transmission electron microscopy, selected area electrondiffraction, and X-ray diffraction spectroscopy. The magnetic characteristics were measured using asuperconducting quantum interference device. The heating properties of these magnetic electrospunnanoﬁber matrices in an alternating magnetic ﬁeld were investigated at a frequency of 750 kHz and mag-netic intensity of 6.4 kW. In vitro cell incubation experiments indicated that these magnetic electrospunnanoﬁber matrices are non-cytotoxic and can effectively reduce tumor cell proliferation upon applicationof a magnetic ﬁeld.
Date:	2012-07
Relation:	Acta Biomaterialia. 2012 Jul;8(7):2704-2711.
Link to:	http://dx.doi.org/10.1016/j.actbio.2012.03.045
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1742-7061&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000306442400029
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84861603069
Appears in Collections:	[Feng-Huei Lin] Periodical Articles

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