國家衛生研究院 NHRI:Item 3990099045/6555
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    题名: Anti-influenza drug discovery: Identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization
    作者: Yeh, JY;Coumar, MS;Shiao, HY;Lin, TJ;Lee, YC;Hung, HC;Ko, S;Kuo, FM;Fang, MY;Huang, YL;Hsu, JT;Yeh, TK;Shih, SR;Chao, YS;Horng, JT;Hsieh, HP
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: From a high-throughput screening (HTS) hit with inhibitory activity against virus-induced cytophathic in the low micromolar range, we have developed a potent anti-influenza lead through careful optimization without compromising the drug-like properties of the compound. An orally bioavailable compound was identified as a lead agent with nanomolar activity against influenza, representing a 140-fold improvement over the initial hit.
    日期: 2012-09
    關聯: ChemMedChem. 2012 Sep;7(9):1546-1550.
    Link to: http://dx.doi.org/10.1002/cmdc.201200259
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1860-7179&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000308042000004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84865598860
    显示于类别:[謝興邦] 期刊論文
    [葉燈光] 期刊論文
    [徐祖安] 期刊論文
    [趙宇生(2002-2013)] 期刊論文

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