國家衛生研究院 NHRI:Item 3990099045/6560

NHRI > Institute of Biomedical Engineering and Nanomedicine > Chung-Shi Yang > Periodical Articles > Item 3990099045/6560

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6560

Title:	Very small photoluminescent gold nanoparticles for multimodality biomedical imaging
Authors:	Lai, SF;Chien, CC;Chen, WC;Chen, HH;Chen, YY;Wang, CL;Hwu, Y;Yang, CS;Chen, CY;Liang, KS;Petibois, C;Tan, HR;Tok, ES;Margaritondo, G
Contributors:	Center for Nanomedicine Research
Abstract:	An original synthesis method based on X-ray irradiation produced gold nanoparticles (AuNPs) with two important properties for biomedical research: intense visible photoluminescence and very high accumulation in cancer cells. The nanoparticles, coated with MUA (11-mercaptoundecanoid acid), are very small (1.4 nm diameter); the above two properties are not present for even slightly larger sizes. The small MUA-AuNPs are non-cytotoxic (except for very high concentrations) and do not interfere with cancer cell proliferation. Multimodality imaging using visible light fluorescence and X-ray microscopy is demonstrated by tracing the nanoparticle-loaded tumor cells.
Date:	2013-05
Relation:	Biotechnology Advances. 2013 May;31(3):362-368.
Link to:	http://dx.doi.org/10.1016/j.biotechadv.2012.05.005
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0734-9750&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000317441900002
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84875055833
Appears in Collections:	[Chung-Shi Yang] Periodical Articles

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