國家衛生研究院 NHRI:Item 3990099045/6743

NHRI > National Institute of Infectious Diseases and Vaccinology > Guann-Yi Yu > Periodical Articles > Item 3990099045/6743

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6743

Title:	Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production
Authors:	Yu, GY;He, G;Li, CY;Tang, M;Grivennikov, S;Tsai, WT;Wu, MS;Hsu, CW;Tsai, Y;Wang, Lily?HC;Karin, M
Contributors:	Division of Infectious Diseases
Abstract:	nnate immunity controls pathogen replication and spread. Yet, certain pathogens, such as Hepatitis C Virus (HCV), escape immune elimination and establish persistent infections that promote chronic inflammation and related diseases. Whereas HCV regulatory proteins that attenuate antiviral responses are known, those that promote inflammation and liver injury remain to be identified. Here, we show that transient expression of HCV RNA-dependent RNA polymerase (RdRp), NS5B, in mouse liver and human hepatocytes results in production of small RNA species that activate innate immune signaling via TBK1-IRF3 and NF-κB and induce cytokine production, including type I interferons (IFN) and IL-6. NS5B-expression also results in liver damage.
Date:	2012-10
Relation:	Molecular Cell. 2012 Oct;48(2):313-321.
Link to:	http://dx.doi.org/10.1016/j.molcel.2012.07.032
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1097-2765&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000310423800016
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84868090808
Appears in Collections:	[Guann-Yi Yu] Periodical Articles

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