國家衛生研究院 NHRI:Item 3990099045/6743
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    題名: Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production
    作者: Yu, GY;He, G;Li, CY;Tang, M;Grivennikov, S;Tsai, WT;Wu, MS;Hsu, CW;Tsai, Y;Wang, Lily?HC;Karin, M
    貢獻者: Division of Infectious Diseases
    摘要: nnate immunity controls pathogen replication and spread. Yet, certain pathogens, such as Hepatitis C Virus (HCV), escape immune elimination and establish persistent infections that promote chronic inflammation and related diseases. Whereas HCV regulatory proteins that attenuate antiviral responses are known, those that promote inflammation and liver injury remain to be identified. Here, we show that transient expression of HCV RNA-dependent RNA polymerase (RdRp), NS5B, in mouse liver and human hepatocytes results in production of small RNA species that activate innate immune signaling via TBK1-IRF3 and NF-κB and induce cytokine production, including type I interferons (IFN) and IL-6. NS5B-expression also results in liver damage.
    日期: 2012-10
    關聯: Molecular Cell. 2012 Oct;48(2):313-321.
    Link to: http://dx.doi.org/10.1016/j.molcel.2012.07.032
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1097-2765&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000310423800016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84868090808
    顯示於類別:[余冠儀] 期刊論文

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