國家衛生研究院 NHRI:Item 3990099045/6872
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6872


    Title: Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity
    Authors: Shih, HJ;Chen, HH;Chen, YA;Wu, MH;Liou, GG;Chang, WW;Chen, LY;Wang, LH;Hsu, HL
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: Overexpression of Shc adaptor proteins is associated with mitogenesis, carcinogenesis and metastasis. Multiple copies in T-cell malignancy 1 (MCT-1) oncoprotein promotes cell proliferation, survival and tumorigenic effects. Our current data show that MCT-1 is a novel regulator of Shc-Ras-MEK-ERK signaling and MCT-1 is significantly co-activated with Shc gene in human carcinomas. The knockdown of MCT-1 enhances apoptotic cell death accompanied with the activation of caspases and cleavage of caspase substrates under environmental stress. The cancer cell proliferation, chemo-resistance and tumorigenic capacity are proved to be effectively suppressed by targeting MCT-1. Accordingly, an important linkage between MCT-1 oncogenicity and Shc pathway in tumor development has now been established. Promoting MCT-1 expression by gene hyperactivation may be recognized as a tumor marker and MCT-1 may serve as a molecular target of cancer therapy.
    Date: 2012-11
    Relation: Oncotarget. 2012 Nov;3(11):1401-1415.
    Link to: http://dx.doi.org/10.18632/oncotarget.688
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000312483600019
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84872798883
    Appears in Collections:[Hsin-Ling Hsu] Periodical Articles
    [Gan-Guang Liou(2006-2014)] Periodical Articles
    [Lu-Hai Wang] Periodical Articles

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