國家衛生研究院 NHRI:Item 3990099045/6872
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    题名: Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity
    作者: Shih, HJ;Chen, HH;Chen, YA;Wu, MH;Liou, GG;Chang, WW;Chen, LY;Wang, LH;Hsu, HL
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Overexpression of Shc adaptor proteins is associated with mitogenesis, carcinogenesis and metastasis. Multiple copies in T-cell malignancy 1 (MCT-1) oncoprotein promotes cell proliferation, survival and tumorigenic effects. Our current data show that MCT-1 is a novel regulator of Shc-Ras-MEK-ERK signaling and MCT-1 is significantly co-activated with Shc gene in human carcinomas. The knockdown of MCT-1 enhances apoptotic cell death accompanied with the activation of caspases and cleavage of caspase substrates under environmental stress. The cancer cell proliferation, chemo-resistance and tumorigenic capacity are proved to be effectively suppressed by targeting MCT-1. Accordingly, an important linkage between MCT-1 oncogenicity and Shc pathway in tumor development has now been established. Promoting MCT-1 expression by gene hyperactivation may be recognized as a tumor marker and MCT-1 may serve as a molecular target of cancer therapy.
    日期: 2012-11
    關聯: Oncotarget. 2012 Nov;3(11):1401-1415.
    Link to: http://dx.doi.org/10.18632/oncotarget.688
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000312483600019
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84872798883
    显示于类别:[徐欣伶] 期刊論文
    [劉淦光(2006-2014)] 期刊論文
    [王陸海] 期刊論文

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