國家衛生研究院 NHRI:Item 3990099045/7116

NHRI > Institute of Biotechnology and Pharmaceutical Research > Shiow-Lin Pan(2009-2013) > Periodical Articles > Item 3990099045/7116

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7116

Title:	Azatyrosinamides: Novel RAS-related anticancer agents
Authors:	Wang, CL;Lee, O;Huang, CF;Li, EIC;Teng, CM;Pan, SL;Lian, JF;Chang, FS;Liou, JP;Wang, HP
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	Background: We previously reported on the design and synthesis of novel azatyrosinamide derivatives selective for ras-transformed NIH3T3 cells and with improved toxicity over azatyrosine. This study was aimed at investigating the mechanism of action and the antitumour activity of these compounds in ras-transformed cells. Materials and Methods: Nine azatyrosinamides were previously screened for anticancer activity in both wild-type and ras-transformed NIH3T3 cells; the most active compounds were further tested in vitro and in vivo. Results: HPW98-1 and HPW98-2 induced formation of apoptotic bodies in ras-transformed NIH3T3 cells in vitro and inhibited anchorage-independent growth. Excess tyrosine reduced the cytotoxic effect of azatyrosine, but not of HPW98-1 and HPW98-2. HPW98-1 reduced vascular endothelial growth factor-mediated angiogenesis in a Matrigel plug assay and attenuated growth of a ras-transformed NIH3T3 xenograft and a human SW620 xenograft. Conclusion: Our results support the continued study of HPW98-1 for its potential use in the treatment of RAS-related cancers.
Date:	2013-02
Relation:	Anticancer Research. 2013 Feb;33(2):425-432.
Link to:	http://ar.iiarjournals.org/content/33/2/425.abstract
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0250-7005&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000315424000011
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84875893675
Appears in Collections:	[Shiow-Lin Pan(2009-2013)] Periodical Articles

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