國家衛生研究院 NHRI:Item 3990099045/7116
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    題名: Azatyrosinamides: Novel RAS-related anticancer agents
    作者: Wang, CL;Lee, O;Huang, CF;Li, EIC;Teng, CM;Pan, SL;Lian, JF;Chang, FS;Liou, JP;Wang, HP
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Background: We previously reported on the design and synthesis of novel azatyrosinamide derivatives selective for ras-transformed NIH3T3 cells and with improved toxicity over azatyrosine. This study was aimed at investigating the mechanism of action and the antitumour activity of these compounds in ras-transformed cells. Materials and Methods: Nine azatyrosinamides were previously screened for anticancer activity in both wild-type and ras-transformed NIH3T3 cells; the most active compounds were further tested in vitro and in vivo. Results: HPW98-1 and HPW98-2 induced formation of apoptotic bodies in ras-transformed NIH3T3 cells in vitro and inhibited anchorage-independent growth. Excess tyrosine reduced the cytotoxic effect of azatyrosine, but not of HPW98-1 and HPW98-2. HPW98-1 reduced vascular endothelial growth factor-mediated angiogenesis in a Matrigel plug assay and attenuated growth of a ras-transformed NIH3T3 xenograft and a human SW620 xenograft. Conclusion: Our results support the continued study of HPW98-1 for its potential use in the treatment of RAS-related cancers.
    日期: 2013-02
    關聯: Anticancer Research. 2013 Feb;33(2):425-432.
    Link to: http://ar.iiarjournals.org/content/33/2/425.abstract
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0250-7005&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000315424000011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84875893675
    顯示於類別:[潘秀玲(2009-2013)] 期刊論文

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