國家衛生研究院 NHRI:Item 3990099045/7254
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12500/13673 (91%)
造訪人次 : 2563032      線上人數 : 486
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/7254


    題名: Influence of the extracellular matrix stiffness in tissue-engineered constructs on deformed cell shapes under large compressive deformations
    作者: Ben-Or, M;Shoham, N;Lin, FH;Gefen, A
    貢獻者: Division of Medical Engineering Research
    摘要: Production of tissue-engineered constructs could sometimes involve delivery of compressive mechanical stimulations to the constructs in order to promote synthesis of extracellular matrix (ECM) components or cell differentiation. Here we developed a set of finite element models to determine how could the ECM/cells stiffness ratio influence the extent of shape distortions of initially round embedded cells, which has been quantified by means of the cell shape index (CSI). We found that below a 12% construct strain threshold, the ECM/cells stiffness ratio did not appear to influence the CSI and hence the extent of cellular distortion in the construct. For greater construct strains, the mean CSI of cells decreased (i.e., cells became more flattened and stretched) quadratically with the level of the global ECM-cell strain. For ECMs that were softer than the cells, the CSI decreased slightly, by no more than 0.1, even under very large construct strains (> 50% strain), so a roughly round or oval cell shape was overall maintained. For stiff ECMs which were 10-times or 100-times stiffer than the embedded cells, the CSI dropped substantially with the extent of global ECM-cell strains, by up to approximately 0.4 and 0.5, respectively, so cells became considerably flattened and stretched. These data are useful for predicting cell shape distortions in construct compression experiments, where ECM/cell stiffness ratios can be empirically evaluated.
    日期: 2013-04
    關聯: Journal of Biomaterials and Tissue Engineering. 2013 Apr;3(2):240-243.
    Link to: http://dx.doi.org/10.1166/jbt.2013.1086
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000317942400010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84891588071
    顯示於類別:[林峯輝] 期刊論文

    文件中的檔案:

    沒有與此文件相關的檔案.



    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋