國家衛生研究院 NHRI:Item 3990099045/7348
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    題名: Candida albicans ENO1 null mutants exhibit altered drug susceptibility, hyphal formation, and virulence
    作者: Ko, HC;Hsiao, TY;Chen, CT;Yang, YL
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: We previously showed that the expression of ENO1 (enolase) in the fungal pathogen Candida albicans is critical for cell growth. In this study, we investigate the contribution of the ENO1 gene to virulence. We conducted our functional study of ENO1 in C. albicans by constructing an eno1/eno1 null mutant strain in which both ENO1 alleles in the genome were knockouted with the SAT1 flipper cassette that contains the nourseothricin-resistance marker. Although the null mutant failed to grow on synthetic media containing glucose, it was capable of growth on media containing yeast extract, peptone, and non-fermentable carbon sources. The null mutant was more susceptible to certain antifungal drugs. It also exhibited defective hyphal formation, and was avirulent in BALB/c mice.
    日期: 2013-06
    關聯: Journal of Microbiology. 2013 Jun;51(3):345-351.
    Link to: http://dx.doi.org/10.1007/s12275-013-2577-z
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1225-8873&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000321134100012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84879627876
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