國家衛生研究院 NHRI:Item 3990099045/7527

NHRI > National Institute of Infectious Diseases and Vaccinology > Ih-Jen Su(2002-2015) > Periodical Articles > Item 3990099045/7527

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7527

Title:	High-incidence of human adenoviral co-infections in Taiwan
Authors:	Wang, SL;Chi, CY;Kuo, PH;Tsai, HP;Wang, SM;Liu, CC;Su, IJ;Wang, JR
Contributors:	Division of Infectious Diseases
Abstract:	Background:Respiratory infections caused by adenovirus (HAdV) are common year round. Recently, a significant increase of adenoviral infections was observed in Taiwan.Objective:To understand the prevalence and molecular epidemiology of respiratory adenovirus circulating in Taiwan for the past decade.Study Design:One hundred and twenty-six human adenoviruses, isolated between 2002 to 2011, were characterized via DNA sequencing of the hexon and fiber genes. The nucleotide sequences were then compared by phylogenetic analysis.Results:HAdV-B3 accounted for 64.3% (81/126) and peaked almost every year, whereas the sequences of hexon and fiber genes of HAdV-B3 were highly conserved in different years. A high incidence of co-infection of adenoviruses was observed (19.0%, 24/126); HAdV-B3 co-infected with HAdV-C2 was the most common combination (58.3%, 14/24). An additional interesting finding of repeated infection was noted in 10 children, all of whom showed first infection with adenovirus species HAdV-C, followed by species HAdV-B or HAdV-E.Conclusions:HAdV-B3 was the predominant type of respiratory adenovirus circulating in Taiwan over the past ten years. This merits further attention for vaccine development. Furthermore, the observed high-incidence of adenoviral co-infections along with repeated infections found in our study provides important epidemiological insights into adenovirus infections.
Date:	2013-09-20
Relation:	PLoS ONE. 2013 Sep 20;8(9):Article numbere75208.
Link to:	http://dx.doi.org/10.1371/journal.pone.0075208
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000324768000063
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84884490538
Appears in Collections:	[Ih-Jen Su(2002-2015)] Periodical Articles [Chia-Yu Chi] Periodical Articles

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