國家衛生研究院 NHRI:Item 3990099045/7527
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    题名: High-incidence of human adenoviral co-infections in Taiwan
    作者: Wang, SL;Chi, CY;Kuo, PH;Tsai, HP;Wang, SM;Liu, CC;Su, IJ;Wang, JR
    贡献者: Division of Infectious Diseases
    摘要: Background:Respiratory infections caused by adenovirus (HAdV) are common year round. Recently, a significant increase of adenoviral infections was observed in Taiwan.Objective:To understand the prevalence and molecular epidemiology of respiratory adenovirus circulating in Taiwan for the past decade.Study Design:One hundred and twenty-six human adenoviruses, isolated between 2002 to 2011, were characterized via DNA sequencing of the hexon and fiber genes. The nucleotide sequences were then compared by phylogenetic analysis.Results:HAdV-B3 accounted for 64.3% (81/126) and peaked almost every year, whereas the sequences of hexon and fiber genes of HAdV-B3 were highly conserved in different years. A high incidence of co-infection of adenoviruses was observed (19.0%, 24/126); HAdV-B3 co-infected with HAdV-C2 was the most common combination (58.3%, 14/24). An additional interesting finding of repeated infection was noted in 10 children, all of whom showed first infection with adenovirus species HAdV-C, followed by species HAdV-B or HAdV-E.Conclusions:HAdV-B3 was the predominant type of respiratory adenovirus circulating in Taiwan over the past ten years. This merits further attention for vaccine development. Furthermore, the observed high-incidence of adenoviral co-infections along with repeated infections found in our study provides important epidemiological insights into adenovirus infections.
    日期: 2013-09-20
    關聯: PLoS ONE. 2013 Sep 20;8(9):Article numbere75208.
    Link to: http://dx.doi.org/10.1371/journal.pone.0075208
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000324768000063
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84884490538
    显示于类别:[蘇益仁(2002-2015)] 期刊論文
    [齊嘉鈺] 期刊論文

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