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http://ir.nhri.org.tw/handle/3990099045/7649
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| Title: | Association between recent use of fluoroquinolones and rhegmatogenous retinal detachment: A population-based cohort study |
| Authors: | Kuo, SC;Chen, YT;Lee, YT;Fan, NW;Chen, SJ;Li, SY;Liu, CJ;Chen, TL;Chen, TJ;Fung, CP |
| Contributors: | Division of Infectious Diseases |
| Abstract: | Background: An association between use of oral fluoroquinolones (FQs) and retinal detachment remains controversial. This study was to determine the association of recent use of oral FQs and rhegmatogenous retinal detachment (RRD) after adjustment for confounding factors known to be associated with RRD.Methods:This retrospective population-based cohort study with parallel groups included adults treated with an oral FQ (FQ cohort 178 179 prescriptions) and propensity-score–matched adults treated with oral amoxicillin (amoxicillin cohort 178 179 prescriptions). The data were extracted from the Taiwan National Health Insurance Research Database from 1998 to 2010. Interaction terms were used to identify populations at risk. RRD was defined according to the International Classification of Disease, ninth revision.Results:During the 90-day follow-up period, 96 patients (0.054%) in the FQ cohort developed RRD compared to 46 (0.026%) among the matched amoxicillin cohort. The overall adjusted hazard ratio (aHR) for FQ use and RRD was 2.07 (95% confidence interval [CI], 1.45-2.96). The interval between use of oral FQs and onset of RRD was 35.5 days (interquartile range, 14-57). Interaction terms were not significant for age, sex, diabetes, indications for antimicrobials and underlying ophthalmic conditions. The aHRs differed for specific FQs. These were ciprofloxacin 10.68 (95% CI, 3.28-34.82), levofloxacin 2.41 (0.76-7.68), norfloxacin 2.00 (1.06-3.79), and ofloxacin 1.17 (0.59-2.31).Conclusions:The use of oral FQs was associated with the subsequent occurrence of RRD. The FQ risk was independent of age, sex, diabetes, indications for antimicrobials, or underlying ophthalmic conditions. Certain FQs carried higher risk of RRD. |
| Date: | 2014-01 |
| Relation: | Clinical Infectious Diseases. 2014 Jan;58(2):197-203. |
| Link to: | http://dx.doi.org/10.1093/cid/cit708 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1058-4838&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000329131300011 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84891792341 |
| Appears in Collections: | [郭書辰] 期刊論文
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Size | Format | |
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| PB2013112601.pdf | | 236Kb | Adobe PDF | 455 | View/Open |
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