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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/7908
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| Title: | Multiplexed immunoglobulin E sensitization in relation to exhaled nitric oxide in a population sample of children |
| Authors: | Yao, TC;Tsai, HJ;Tu, YL;Chang, SW;Hua, MC;Liao, SL;Tsai, MH;Chiu, CY;Lai, SH;Yeh, KW;Huang, JL |
| Contributors: | Division of Biostatistics and Bioinformatics |
| Abstract: | This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mites (P < 0.001), animals (P = 0.001), cockroaches (P < 0.001), and foods (P = 0.042), and furthermore, between FeNO and the number of sensitizations (all P < 0.05) or the sum of specific IgE (all P ≤ 0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher FeNO: Dermatophagoides pteronyssinus, Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental cockroach, codfish, crab, shrimp, and cheese (all P ≤ 0.01). In conclusion, IgE sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated FeNO levels in a dose-dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways. |
| Date: | 2014-05 |
| Relation: | Allergy: European Journal of Allergy and Clinical Immunology. 2014 May;69(5):678-682. |
| Link to: | http://dx.doi.org/10.1111/all.12378 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000333816900016 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84898482279 |
| Appears in Collections: | [蔡慧如] 期刊論文
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| SCP84894527973.pdf | | 279Kb | Adobe PDF | 398 | View/Open |
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