邻近类别 會議論文/會議摘要 [3/4] 專利 [0/7] 类别统计 近3年内发表的文件:4(13.79%) 含全文笔数:28(96.55%) 文件下载次数统计 下载大于0次:28(100.00%) 下载大于100次:27(96.43%) 全文下载总次数:19299(91.59%) 最后更新时间: 2024-11-28 18:43 上传排行 数据加载中..... 下载排行 数据加载中..... 最近上传 Decrypting orphan GPCR drug discove... Natural fucoidans inhibit coronavir... Modulating the affinity and signali... Discovery and development of a nove... Unique sulfur-aromatic interactions... A structure-function approach ident... Fluorine-18 isotope labeling for po... Median nerve stimulation induces an... DUSP6 mediates T cell receptor-enga... 4-Bromophenylhydrazinyl benzenesulf...

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日期	题名	關聯
2024-01-23	Decrypting orphan GPCR drug discovery via multitask learning	Journal of Cheminformatics. 2024 Jan 23;16:Article number 10.
2023-07-20	Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin	Biochemical Pharmacology. 2023 Jul 20;215:Article number 115688.
2023-01	Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists	Bioorganic Chemistry. 2023 Jan;130:Article number 106236.
2022-02-05	Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design	European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043.
2020-02-10	Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors	Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659.
2019-08	A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes	Biochemical Pharmacology. 2019 Aug;166:203-211.
2019-01-01	Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist	Bioorganic and Medicinal Chemistry. 2019 Jan 1;27(1):216-223.
2018-10-06	Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray	Proceedings of the National Academy of Sciences of the United States of America. 2018 Nov;115(45):E10720-E10729.
2018-08-21	DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation	Proceedings of the National Academy of Sciences of the United States of America. 2018 Aug 21;115(34):E8027-E8036.
2018-04	4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy	Bioorganic Chemistry. 2018 Apr;77:600-607.
2017-11	Caveolin-1 secreted from adipose tissues and adipocytes functions as an adipogenesis enhancer	Obesity. 2017 Nov;25(11):1932-1940.
2016-07-22	Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons	Nature Communications. 2016 Jul 22;7:Article number 12199.
2016-01	Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1	Journal of Medicinal Chemistry. 2016 Jan;59 (1):282-293.
2016-01	Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy	Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430.
2015-10	Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening	Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
2015-05	A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis	Diabetes, Obesity and Metabolism. 2015 May;17(5):495-504.
2014-08	Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors	Bioorganic and Medicinal Chemistry Letters. 2014 Aug;24(15):3403-3406.
2013-11-13	Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice	Journal of Medicinal Chemistry. 2013 Nov 13;56(24):9920-9933.
2013-05	Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines	Journal of Immunology. 2013 May;190(10):5065-5077.
2012-07	Induction of fatty acid oxidation resists weight gain, ameliorates hepatic steatosis and reduces cardiometabolic risk factors	International Journal of Obesity. 2012 Jul;36(7):999-1006.
2011-06	A new perspective of cannabinoid 1 receptor antagonists: Approaches toward peripheral CB1R blockers without crossing the blood-brain barrier	Current Topics In Medicinal Chemistry. 2011 Jun;11(12):1421-1429.
2011-01-13	Discovery of novel N -Beta- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes	Journal of Medicinal Chemistry. 2011 Jan 13;54(1):166-178.
2010-10	Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities	Pharmacological Research. 2010 Oct;62(4):337-343.
2010-09	Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist	ChemMedChem. 2010 Sep;5(9):1439-1443.
2009-07-23	Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice	Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4496-4510.

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