國家衛生研究院 NHRI:Item 3990099045/8203
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 915566      在线人数 : 1259
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8203


    题名: Cyclin-dependent kinase 4 overexpression confers an independent prognosticator of nasopharyngeal carcinoma
    作者: Chen, TJ;Lee, YY;Li, CF
    贡献者: National Institute of Cancer Research
    摘要: Background:Data mining on a public domain demonstrated that cyclin dependent kinase 4 (CDK4) was highly expressed in nasopharyngeal carcinoma (NPC). Associated with cyclin-D, CDK4 phosphorylates and inactivates retinoblastoma (Rb) protein family members and mediates progression through G1 to S-phase in the cell cycle. Overexpression of CDK4 has been identified in oral squamous cell carcinoma, lung and breast cancers, sarcomas, and melanomas. However, the expression of CDK4 has never been reported in NPC. This study investigated the expression status, correlation with clinicopathological features, and prognostic implications of CDK4 in a well-defined cohort of NPC. Methods: We retrospectively assessed CDK4 immunoexpression in biopsies of 124 consecutive NPC patients who did not have initial distant metastasis and who received treatment according to consistent guidelines. The results were correlated with clinicopathological features, local recurrence-free survival (LRFS), distant metastasis-free survival (DMeFS), and disease-specific survival (DSS). Findings: High levels of CDK4 protein were positively correlated with T3,4 status (p = 0.024), N2,3 status (p < 0.001), and American Joint Committee on Cancer stage III, IV (p < 0.001). Multivariate analysis suggested that high CDK4 expression was an independent prognostic indicator for worse DMeFS (p = 0.001, hazard ratio [HR] 3.226) and DSS (p = 0.037, HR 1.838). Interpretation:CDK4 overexpression represents a potential prognostic biomarker in NPC and may confer tumour aggressiveness through cell cycle dysregulation.
    日期: 2014-05
    關聯: European Journal of Cancer. 2014 May;50(Suppl. 4):e68.
    Link to: http://dx.doi.org/10.1016/j.ejca.2014.03.254
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0959-8049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000351589200192
    显示于类别:[其他] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    SDO0959804914005267.pdf38KbAdobe PDF498检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈