國家衛生研究院 NHRI:Item 3990099045/8203
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    題名: Cyclin-dependent kinase 4 overexpression confers an independent prognosticator of nasopharyngeal carcinoma
    作者: Chen, TJ;Lee, YY;Li, CF
    貢獻者: National Institute of Cancer Research
    摘要: Background:Data mining on a public domain demonstrated that cyclin dependent kinase 4 (CDK4) was highly expressed in nasopharyngeal carcinoma (NPC). Associated with cyclin-D, CDK4 phosphorylates and inactivates retinoblastoma (Rb) protein family members and mediates progression through G1 to S-phase in the cell cycle. Overexpression of CDK4 has been identified in oral squamous cell carcinoma, lung and breast cancers, sarcomas, and melanomas. However, the expression of CDK4 has never been reported in NPC. This study investigated the expression status, correlation with clinicopathological features, and prognostic implications of CDK4 in a well-defined cohort of NPC. Methods: We retrospectively assessed CDK4 immunoexpression in biopsies of 124 consecutive NPC patients who did not have initial distant metastasis and who received treatment according to consistent guidelines. The results were correlated with clinicopathological features, local recurrence-free survival (LRFS), distant metastasis-free survival (DMeFS), and disease-specific survival (DSS). Findings: High levels of CDK4 protein were positively correlated with T3,4 status (p = 0.024), N2,3 status (p < 0.001), and American Joint Committee on Cancer stage III, IV (p < 0.001). Multivariate analysis suggested that high CDK4 expression was an independent prognostic indicator for worse DMeFS (p = 0.001, hazard ratio [HR] 3.226) and DSS (p = 0.037, HR 1.838). Interpretation:CDK4 overexpression represents a potential prognostic biomarker in NPC and may confer tumour aggressiveness through cell cycle dysregulation.
    日期: 2014-05
    關聯: European Journal of Cancer. 2014 May;50(Suppl. 4):e68.
    Link to: http://dx.doi.org/10.1016/j.ejca.2014.03.254
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0959-8049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000351589200192
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