國家衛生研究院 NHRI:Item 3990099045/8234

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Title:	Effects of dipeptidyl peptidase-4 inhibition with MK-0431 on syngeneic mouse islet transplantation
Authors:	Juang, JH;Kuo, CH;Liu, YH;Chang, HY;Chen, CT
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	Dipeptidyl peptidase (DPP)-4 inhibitors increase circulating levels of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide which may promote beta-cell proliferation and survival. This study tested if DPP-4 inhibition with MK-0431 is beneficial for diabetic mice syngeneically transplanted with a marginal number of islets. We syngeneically transplanted 150 C57BL/6 mouse islets under the kidney capsule of each streptozotocin-diabetic mouse and then treated recipients with (n = 21) or without (n = 17) MK-0431 (30 mg/kg/day, po) for 6 weeks. After islet transplantation, blood glucose levels decreased in both MK-0431-treated and control groups. However, the blood glucose and area under the curve of the intraperitoneal glucose tolerance test at 2, 4, and 6 weeks were not significantly different between MK-0431-treated mice and controls. During 6 weeks, both groups exhibited increased body weights over time. However, the weight between two groups did not differ throughout the study period. At 6 weeks after transplantation, the graft beta-cell mass (0.024 +/- 0.005 versus 0.023 +/- 0.007 mg, P = 0.8793) and insulin content (140 +/- 48 versus 231 +/- 63 ng, P = 0.2939) were comparable in the MK-0431-treated group and controls. Our results indicate posttransplant DPP-4 inhibition with MK-0431 in the diabetic recipient with a marginal number of islets is not beneficial to transplantation outcome or islet grafts.
Date:	2014-08-04
Relation:	International Journal of Endocrinology. 2014 Aug 4;2014:Article ID 795283.
Link to:	http://dx.doi.org/10.1155/2014/795283
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1687-8337&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000340406600001
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84935022389
Appears in Collections:	[Chiung-Tong Chen] Periodical Articles

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