國家衛生研究院 NHRI:Item 3990099045/8546

NHRI > Institute of Biotechnology and Pharmaceutical Research > Kak-Shan Shia > Periodical Articles > Item 3990099045/8546

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8546

Title:	Stem cell mobilizers targeting chemokine receptor CXCR4: Renoprotective application in acute kidney injury
Authors:	Wu, CH;Song, JS;Chang, KH;Jan, JJ;Chen, CT;Chou, MC;Yeh, KC;Wong, YC;Tseng, CT;Wu, SH;Yeh, CF;Huang, CY;Wang, MH;Sadani, AA;Chang, CP;Cheng, CY;Tsou, LK;Shia, KS
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	We have discovered a novel series of quinazoline-based CXCR4 antagonists. Of these, compound 19 mobilized CXCR4+ cell types, including hematopoietic stem cells and endothelial progenitor cells, more efficiently than the marketed 1 (AMD3100) with subcutaneous administration at the same dose (6 mg/kg) in mice. This series of compounds thus provides a set of valuable tools to study diseases mediated by the CXCR4/SDF-1 axis, including myocardial infarction, ischemic stroke, and cancer metastasis. More importantly, treatment with compound 19 significantly lowered levels of blood urea nitrogen and serum creatinine in rats with renal ischemia-reperfusion injury, providing evidence for its therapeutic potential in preventing ischemic acute kidney injury. CXCR4 antagonists such as 19 might also be useful to increase circulating levels of adult stem cells, thereby exerting beneficial effects on damaged and/or inflamed tissues in diseases that currently are not treated by standard approaches.
Date:	2015-03
Relation:	Journal of Medicinal Chemistry. 2015 Mar;58(5):2315-2325.
Link to:	http://dx.doi.org/10.1021/jm501769r
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000351186500020
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84924692156
Appears in Collections:	[Kak-Shan Shia] Periodical Articles [Lun Kelvin Tsou] Periodical Articles [Chiung-Tong Chen] Periodical Articles [Chun-Ping Chang] Periodical Articles

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