國家衛生研究院 NHRI:Item 3990099045/8753

NHRI > Institute of Biomedical Engineering and Nanomedicine > Feng-Huei Lin > Periodical Articles > Item 3990099045/8753

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8753

Title:	Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
Authors:	Liao, SH;Liu, CH;Bastakoti, BP;Suzuki, N;Chang, Y;Yamauchi, Y;Lin, FH;Wu, KCW
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG(2)) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.
Date:	2015-05-04
Relation:	International Journal of Nanomedicine. 2015 May 4;10:3315-3328.
Link to:	http://dx.doi.org/10.2147/ijn.s68719
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1178-2013&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000353889000001
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929448713
Appears in Collections:	[Feng-Huei Lin] Periodical Articles [Chia-Wen Wu] Periodical Articles

Files in This Item:

File	Description	Size	Format
ISI000353889000001.pdf		3131Kb	Adobe PDF	509	View/Open

Loading...