國家衛生研究院 NHRI:Item 3990099045/8753
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    題名: Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
    作者: Liao, SH;Liu, CH;Bastakoti, BP;Suzuki, N;Chang, Y;Yamauchi, Y;Lin, FH;Wu, KCW
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG(2)) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.
    日期: 2015-05-04
    關聯: International Journal of Nanomedicine. 2015 May 4;10:3315-3328.
    Link to: http://dx.doi.org/10.2147/ijn.s68719
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1178-2013&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000353889000001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929448713
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