國家衛生研究院 NHRI:Item 3990099045/8858

NHRI > Institute of Biotechnology and Pharmaceutical Research > Chiung-Tong Chen > Periodical Articles > Item 3990099045/8858

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8858

Title:	Self-assembling bubble carriers for oral protein delivery
Authors:	Chuang, EY;Lin, KJ;Lin, PY;Chen, HL;Wey, SP;Mi, FL;Hsiao, HC;Chen, CT;Sung, HW
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	Successful oral delivery of therapeutic proteins such as insulin can greatly improve the quality of life of patients. This study develops a bubble carrier system by loading diethylene triamine pentaacetic acid (DTPA) dianhydride, a foaming agent (sodium bicarbonate; SBC), a surfactant (sodium dodecyl sulfate; SDS), and a protein drug (insulin) in an enteric-coated gelatin capsule. Following oral administration to diabetic rats, the intestinal fluid that has passed through the gelatin capsule saturates the mixture; concomitantly, DTPA dianhydride produces an acidic environment, while SBC decomposes to form CO2 bubbles at acidic pH. The gas bubbles grow among the surfactant molecules (SDS) owing to the expansion of the generated CO2. The walls of the CO2 bubbles consist of a self-assembled film of water that is in nanoscale and may serve as a colloidal carrier to transport insulin and DTPA. The grown gas bubbles continue to expand until they bump into the wall and burst, releasing their transported insulin, DTPA, and SDS into the mucosal layer. The released DTPA and SDS function as protease inhibitors to protect the insulin molecules as well as absorption enhancers to augment their epithelial permeability and eventual absorption into systemic circulation, exerting their hypoglycemic effects.
Date:	2015-09
Relation:	Biomaterials. 2015 Sep;64:115-124.
Link to:	http://dx.doi.org/10.1016/j.biomaterials.2015.06.035
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0142-9612&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000358631300013
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84937434579
Appears in Collections:	[Chiung-Tong Chen] Periodical Articles

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