國家衛生研究院 NHRI:Item 3990099045/9182

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Title:	Studies on antibiotics active against resistant bacteria. Total synthesis of MRSA-active tetarimycin A and its analogues
Authors:	Huang, JK;Yang Lauderdale, TL;Shia, KS
Contributors:	Institute of Biotechnology and Pharmaceutical Research;Division of Infectious Diseases
Abstract:	Making use of the Hauser-Kraus annulation as a key step, the first total synthesis of tetarimycin A has been accomplished in a highly convergent and operationally simple manner. Preliminary SAR not only validated that tetarimycin A exhibited potent activity against MRSA and VRE at a low MIC value but also identified that the hydroxyl group at C-10 was essential for antibacterial activities.
Date:	2015-08-14
Relation:	Organic Letters. 2015 Aug 14;17(17):4248-4251.
Link to:	http://dx.doi.org/10.1021/acs.orglett.5b02039
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1523-7060&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000361087200032
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84941010065
Appears in Collections:	[Kak-Shan Shia] Periodical Articles [Tsai-Ling Yang Lauderdale] Periodical Articles

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