國家衛生研究院 NHRI:Item 3990099045/9182
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    題名: Studies on antibiotics active against resistant bacteria. Total synthesis of MRSA-active tetarimycin A and its analogues
    作者: Huang, JK;Yang Lauderdale, TL;Shia, KS
    貢獻者: Institute of Biotechnology and Pharmaceutical Research;Division of Infectious Diseases
    摘要: Making use of the Hauser-Kraus annulation as a key step, the first total synthesis of tetarimycin A has been accomplished in a highly convergent and operationally simple manner. Preliminary SAR not only validated that tetarimycin A exhibited potent activity against MRSA and VRE at a low MIC value but also identified that the hydroxyl group at C-10 was essential for antibacterial activities.
    日期: 2015-08-14
    關聯: Organic Letters. 2015 Aug 14;17(17):4248-4251.
    Link to: http://dx.doi.org/10.1021/acs.orglett.5b02039
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1523-7060&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000361087200032
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84941010065
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