| 2009-07-23 |
Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice |
Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4496-4510. |
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| 2009-07-23 |
Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity |
Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4221-4233. |
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| 2009-07-15 |
Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor |
Biochemical Pharmacology. 2009 Jul 15;78(2):203-210. |
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| 2009-06 |
A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.] |
European Journal of Medicinal Chemistry. 2009 Jun;44(6):2763-2763. |
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| 2009-04-23 |
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists |
Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2618-2622. |
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| 2009-04-01 |
Design, synthesis, and anti-HCV activity of thiourea compounds |
Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1950-1955. |
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| 2009-04-01 |
Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1908-1912. |
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| 2009-03-15 |
Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors |
Bioorganic and Medicinal Chemistry. 2009 Mar 15;17(6):2388-2399. |
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| 2009-02-26 |
Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity |
Journal of Medicinal Chemistry. 2009 Feb 26;52(4):1050-1062. |
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| 2009-02 |
Aurintricarboxylic acid inhibits influenza virus neuraminidase |
Antiviral Research. 2009 Feb;81(2):123-131. |
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| 2008-10-15 |
Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma |
Bioorganic and Medicinal Chemistry Letters. 2008 Oct 15;18(20):5676-5679. |
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| 2008-09-21 |
Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists |
Organic and Biomolecular Chemistry. 2008 Sep 21;6(18):3399-3407. |
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| 2008-09-11 |
Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists |
Journal of Medicinal Chemistry. 2008 Sep 11;51(17):5397-5412. |
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| 2008-08 |
A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors |
European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611. |
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| 2008-07-09 |
Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice |
International Journal of Pharmaceutics. 2008 Jul;359(1-2):174-181. |
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| 2008-06-01 |
A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors |
Analytical Biochemistry. 2008 Jun;377(1):89-94. |
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| 2008-05 |
Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana |
Phytotherapy Research. 2008 May;22(5):605-613. |
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| 2008-04-01 |
A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71 |
Analytical Biochemistry. 2008 Apr;375(1):115-123. |
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| 2008-03-01 |
Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold |
Bioorganic and Medicinal Chemistry Letters. 2008 Mar;18(5):1623-1627. |
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| 2008-02-07 |
Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists |
Organic and Biomolecular Chemistry. 2008 Feb;6(3):447-450. |
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| 2007-11 |
Novel small-molecule inhibitors of transmissible gastroenteritis virus |
Antimicrobial Agents and Chemotherapy. 2007 Nov;51(11):3924-3931. |
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| 2007-10-01 |
Rapid and sensitive determination of fentanyl in dog plasma by on-line solid-phase extraction integrated with a hydrophilic column coupled to tandem mass spectrometry |
Journal of Chromatography B. 2007 Oct;857(2):195-201. |
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| 2007-07 |
Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes |
Drug Metabolism and Disposition. 2007 Jul;35(7):1042-1049. |
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| 2007-03-01 |
3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes |
Bioorganic and Medicinal Chemistry Letters. 2007 Mar;17(5):1274-1279. |
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| 2007-02-01 |
Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study |
Journal of Chromatography B. 2007 Feb;846(1-2):162-168. |
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