| 2011-02 |
Synthesis of 3,3-dimethylglutamic acid derivatives as DPP-IV inhibitors and evaluation of their chemical stability |
Journal of the Chinese Chemical Society. 2011 Feb;58(1):108-117. |
 |
| 2011-01-13 |
Discovery of novel N -Beta- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes |
Journal of Medicinal Chemistry. 2011 Jan 13;54(1):166-178. |
|
| 2011-01 |
Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay |
Antimicrobial Agents and Chemotherapy. 2011 Jan;55(1):229-238. |
|
| 2011-01 |
BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities |
Cancer Science. 2011 Jan;102(1):182-191. |
|
| 2010-12 |
Discovery of non-glycoside sodium-dependent glucose Co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening |
Journal of Medicinal Chemistry. 2010 Dec;53(24):8770-8774. |
|
| 2010-11 |
Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus |
Antiviral Research. 2010 Nov;88(2):160-168. |
|
| 2010-10-28 |
Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency |
Journal of Medicinal Chemistry. 2010 Oct 28;53(20):7316-7326. |
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| 2010-10 |
Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities |
Pharmacological Research. 2010 Oct;62(4):337-343. |
|
| 2010-10 |
Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists |
ChemMedChem. 2010 Oct;5(10):1707-1716. |
|
| 2010-09-01 |
Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors |
Bioorganic and Medicinal Chemistry. 2010 Sep ;18(17):6414-6421. |
|
| 2010-09 |
Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist |
ChemMedChem. 2010 Sep;5(9):1439-1443. |
|
| 2010-08 |
Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein |
Journal of Medicinal Chemistry. 2010 Aug;53(18):6572-6583. |
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| 2010-07 |
Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075 |
Anticancer Research. 2010 Jul;30(7):2813-2822. |
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| 2010-06-15 |
(2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV |
Bioorganic and Medicinal Chemistry Letters. 2010 Jun 15;20(12):3596-3600. |
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| 2010-06-15 |
Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification |
Journal of Medicinal Chemistry. 2010 Jun 15;53(13):4980-4988. |
|
| 2010-03 |
Synthesis and biological activities of 2-Amino-1-arylidenamino imidazoles as orally active anticancer agents |
Journal of Medicinal Chemistry. 2010 Mar;53(6):2409-2417. |
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| 2010-02-25 |
Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives |
Journal of Medicinal Chemistry. 2010 Feb 25;53(4):1519-1533. |
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| 2010-02-23 |
Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity |
Journal of Biomedical Science. 2010 Feb 23;17:Article number 13. |
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| 2010-02-01 |
Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor |
ChemMedChem. 2010 Feb 1;5(2):255-267. |
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| 2010-02 |
Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91 |
Pharmacological Research. 2010 Feb;61(2):108-115. |
|
| 2010-01 |
BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses |
Journal of Antimicrobial Chemotherapy. 2010 Jan;65(1):63-71. |
|
| 2009-11-01 |
Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2009 Nov 1;19(21):6063-6068. |
|
| 2009-10 |
(1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases |
Journal of the Chinese Chemical Society. 2009 Oct;56(5):1048-1055. |
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| 2009-08-14 |
Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression |
Biochemical and Biophysical Research Communications. 2009 Aug 14;386(1):140-145. |
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| 2009-08-01 |
Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2009 Aug 1;19(15):4134-4138. |
|
| 2009-07-23 |
Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice |
Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4496-4510. |
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| 2009-07-23 |
Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity |
Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4221-4233. |
|
| 2009-07-15 |
Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor |
Biochemical Pharmacology. 2009 Jul 15;78(2):203-210. |
|
| 2009-06 |
A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.] |
European Journal of Medicinal Chemistry. 2009 Jun;44(6):2763-2763. |
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| 2009-04-23 |
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists |
Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2618-2622. |
|
| 2009-04-01 |
Design, synthesis, and anti-HCV activity of thiourea compounds |
Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1950-1955. |
|
| 2009-04-01 |
Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1908-1912. |
|
| 2009-03-15 |
Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors |
Bioorganic and Medicinal Chemistry. 2009 Mar 15;17(6):2388-2399. |
|
| 2009-02-26 |
Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity |
Journal of Medicinal Chemistry. 2009 Feb 26;52(4):1050-1062. |
|
| 2009-02 |
Aurintricarboxylic acid inhibits influenza virus neuraminidase |
Antiviral Research. 2009 Feb;81(2):123-131. |
|
| 2008-10-15 |
Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma |
Bioorganic and Medicinal Chemistry Letters. 2008 Oct 15;18(20):5676-5679. |
|
| 2008-09-21 |
Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists |
Organic and Biomolecular Chemistry. 2008 Sep 21;6(18):3399-3407. |
|
| 2008-09-11 |
Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists |
Journal of Medicinal Chemistry. 2008 Sep 11;51(17):5397-5412. |
|
| 2008-08 |
A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors |
European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611. |
|
| 2008-07-09 |
Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice |
International Journal of Pharmaceutics. 2008 Jul;359(1-2):174-181. |
|
| 2008-06-01 |
A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors |
Analytical Biochemistry. 2008 Jun;377(1):89-94. |
|
| 2008-05 |
Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana |
Phytotherapy Research. 2008 May;22(5):605-613. |
|
| 2008-04-01 |
A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71 |
Analytical Biochemistry. 2008 Apr;375(1):115-123. |
|
| 2008-03-01 |
Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold |
Bioorganic and Medicinal Chemistry Letters. 2008 Mar;18(5):1623-1627. |
|
| 2008-02-07 |
Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists |
Organic and Biomolecular Chemistry. 2008 Feb;6(3):447-450. |
|
| 2007-11 |
Novel small-molecule inhibitors of transmissible gastroenteritis virus |
Antimicrobial Agents and Chemotherapy. 2007 Nov;51(11):3924-3931. |
|
| 2007-10-01 |
Rapid and sensitive determination of fentanyl in dog plasma by on-line solid-phase extraction integrated with a hydrophilic column coupled to tandem mass spectrometry |
Journal of Chromatography B. 2007 Oct;857(2):195-201. |
|
| 2007-07 |
Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes |
Drug Metabolism and Disposition. 2007 Jul;35(7):1042-1049. |
|
| 2007-03-01 |
3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes |
Bioorganic and Medicinal Chemistry Letters. 2007 Mar;17(5):1274-1279. |
|
| 2007-02-01 |
Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study |
Journal of Chromatography B. 2007 Feb;846(1-2):162-168. |
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