國家衛生研究院 NHRI:Item 3990099045/9315
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 914666      在线人数 : 1406
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9315


    题名: Tylophorine compounds exert anti-cancer activity by targeting a ribonucleoprotein complex containing caprin-1 and c-Myc mRNA
    作者: Qiu, YQ;Yang, CW;Lee, YZ;Yang, RB;Lee, CH;Hsu, HY;Chang, CC;Lee, SJ
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Tylophorine and its derivatives exhibit anti-cancer activities, but their cellular targets remain to be elucidated. We used a biotinylated tylophorine derivative to probe for the interacting cellular target(s) of tylophorine. Tylophorine targets and sequesters caprin-1, G3BP1, c-Myc mRNA and cyclin D1/D2 mRNA-associated ribonucleoprotein complexes to the polysomal fractions, thereby repressing the protein expression of the associated mRNA-transcripts. Gene expression profiling and gain-of-c-Myc-function experiments in tylophorine-treated carcinoma cells revealed that the down-regulation of c-Myc contributes to the anti-oncogenic effects of tylophorine. Furthermore, the potent tylophorine derivative dibenzoquinoline-33b elicited a similar effect, as c-Myc protein levels were also decreased in xenograft tumors treated with dibenzoquinoline-33b.Thus, tylophorine compounds exert anti-cancer activity predominantly by targeting and sequestering the caprin-1 protein and c-Myc mRNA associated ribonucleoprotein complex.
    日期: 2015-04
    關聯: FASEB Journal. 2015 Apr;29(1, Suppl.):Abstract number LB132
    Link to: http://www.fasebj.org/content/29/1_Supplement/LB132.short
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000361470500131
    显示于类别:[李秀珠] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000361470500131.pdf48KbAdobe PDF629检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈