國家衛生研究院 NHRI:Item 3990099045/9751

NHRI > Center for Neuropsychiatric Research > Sheng-Chang Wang > Books/Book Section > Item 3990099045/9751

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9751

Title:	Genetic polymorphisms on OPRM1 involved in multiple responses of a methadone maintenance population: Relationships with insomnia, libido, smoking, and chemokines A2
Authors:	Liu, YL;Tsung, JH;Fang, CP;Liu, SW;Lai, CW;Huang, CL;Wang, SC
Contributors:	Center for Neuropsychiatric Research
Abstract:	Abstract The opioid receptor, mu 1 (OPRM1) is a gene that encodes for the mu opioid receptor (MOR). The role of the MOR has been well characterized in both physiological and pharmacological animal studies. Its role in heroin-dependent patients under treatment with the synthetic opioid methadone, however, is unclear. Using a Taiwan methadone maintenance treatment cohort, we have discovered that the genetic polymorphisms on the OPRM1 genetic regions were significantly associated with the severity of smoking. We did this by using the plasma nicotine metabolite cotinine concentrations as indicator, self-reports of methadone-induced insomnia, and change-in-libido side effects, as rated by the treatment emergent symptom scale and the plasma concentrations of macrophage-derived chemokine (MDC). Our results suggest that the OPRM1 genetic variants may be indicators for the severity of smoking, the severity of methadone-induced insomnia and change-in-libido side effects, and the plasma levels of MDC-related immune responses.
Date:	2016-04
Relation:	Neuropathology of Drug Addictions and Substance Misuse. 2016 Apr;3:532-541.
Link to:	http://dx.doi.org/10.1016/B978-0-12-800634-4.00054-8
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84978340372
Appears in Collections:	[Sheng-Chang Wang] Books/Book Section [Yu-Li Liu] Books/Book Section

Files in This Item:

There are no files associated with this item.

Loading...