國家衛生研究院 NHRI:Item 3990099045/9751
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 909456      在线人数 : 738
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9751


    题名: Genetic polymorphisms on OPRM1 involved in multiple responses of a methadone maintenance population: Relationships with insomnia, libido, smoking, and chemokines A2
    作者: Liu, YL;Tsung, JH;Fang, CP;Liu, SW;Lai, CW;Huang, CL;Wang, SC
    贡献者: Center for Neuropsychiatric Research
    摘要: Abstract The opioid receptor, mu 1 (OPRM1) is a gene that encodes for the mu opioid receptor (MOR). The role of the MOR has been well characterized in both physiological and pharmacological animal studies. Its role in heroin-dependent patients under treatment with the synthetic opioid methadone, however, is unclear. Using a Taiwan methadone maintenance treatment cohort, we have discovered that the genetic polymorphisms on the OPRM1 genetic regions were significantly associated with the severity of smoking. We did this by using the plasma nicotine metabolite cotinine concentrations as indicator, self-reports of methadone-induced insomnia, and change-in-libido side effects, as rated by the treatment emergent symptom scale and the plasma concentrations of macrophage-derived chemokine (MDC). Our results suggest that the OPRM1 genetic variants may be indicators for the severity of smoking, the severity of methadone-induced insomnia and change-in-libido side effects, and the plasma levels of MDC-related immune responses.
    日期: 2016-04
    關聯: Neuropathology of Drug Addictions and Substance Misuse. 2016 Apr;3:532-541.
    Link to: http://dx.doi.org/10.1016/B978-0-12-800634-4.00054-8
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84978340372
    显示于类别:[王聲昌] 圖書
    [劉玉麗] 圖書

    文件中的档案:

    没有与此文件相关的档案.



    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈