國家衛生研究院 NHRI:Item 3990099045/9823
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 854781      Online Users : 803
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9823


    Title: Transcriptional regulation and clinical applications of neural stem cells
    Authors: Hsu, YC;Chiu, IM
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Stem cells self-renew and generate various cell types in their respective lineages. They can be derived from blastocysts or reprogrammed from developing and adult tissue sources. Neural stem cells (NSCs), with the characteristics of self-renewal and multipotency, can be isolated from embryonic stem cells, embryonic ectoderm, and developing or adult brain tissues. Adult neurogenesis occurs in two neurogenic regions in the brain: the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone in the dentate gyrus of the hippocampus. These two regions contain neural stem or progenitor cells that can self-renew and differentiate into neurons, astroglial cells and oligodendrocytes. Here, we will review the isolation and characterization of NSCs from ES cells, developing and adult brains. The transcriptional regulation and molecular markers that are used to identify NSCs will also be reviewed. NSCs have been proposed as a promising cellular source for the treatment of diseases in nervous systems. For clinical application of NSCs in neurodegenerative disorders and damaged neurons, we discuss several critical problems that remain to be resolved, such as the reliable sources of neural stem/progenitor cells for autologous transplantation.
    Date: 2011-01
    Relation: Stem Cell Bioengineering and Tissue Engineering Microenvironment. 2011 Jan:355-384.
    Link to: http://dx.doi.org/10.1142/9789812837899_0013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84969704175
    Appears in Collections:[Ing-Ming Chiu] Books/Book Section

    Files in This Item:

    File Description SizeFormat
    SCP4969704175.pdf1060KbAdobe PDF381View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback