國家衛生研究院 NHRI:Item 3990099045/9823
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 857845      線上人數 : 840
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9823


    題名: Transcriptional regulation and clinical applications of neural stem cells
    作者: Hsu, YC;Chiu, IM
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: Stem cells self-renew and generate various cell types in their respective lineages. They can be derived from blastocysts or reprogrammed from developing and adult tissue sources. Neural stem cells (NSCs), with the characteristics of self-renewal and multipotency, can be isolated from embryonic stem cells, embryonic ectoderm, and developing or adult brain tissues. Adult neurogenesis occurs in two neurogenic regions in the brain: the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone in the dentate gyrus of the hippocampus. These two regions contain neural stem or progenitor cells that can self-renew and differentiate into neurons, astroglial cells and oligodendrocytes. Here, we will review the isolation and characterization of NSCs from ES cells, developing and adult brains. The transcriptional regulation and molecular markers that are used to identify NSCs will also be reviewed. NSCs have been proposed as a promising cellular source for the treatment of diseases in nervous systems. For clinical application of NSCs in neurodegenerative disorders and damaged neurons, we discuss several critical problems that remain to be resolved, such as the reliable sources of neural stem/progenitor cells for autologous transplantation.
    日期: 2011-01
    關聯: Stem Cell Bioengineering and Tissue Engineering Microenvironment. 2011 Jan:355-384.
    Link to: http://dx.doi.org/10.1142/9789812837899_0013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84969704175
    顯示於類別:[邱英明] 圖書

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SCP4969704175.pdf1060KbAdobe PDF381檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋