國家衛生研究院 NHRI:Item 3990099045/9970
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9970


    Title: Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice
    Authors: Liu, Z;Kundu-Roy, T;Matsuura, I;Wang, G;Lin, Y;Lou, YR;Barnard, NJ;Wang, XF;Huang, MT;Suh, N;Liu, F
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: Previous studies based on cell culture and xenograft animal models suggest that Smad3 has tumor suppressor function for breast cancer during early stages of tumorigenesis. In this report, we show that DMBA (7,12-dimethylbenz[a]anthracene), a chemical carcinogen, induces mammary tumor formation at a significantly higher frequency in the Smad3 heterozygous mice than in the Smad3 wild type mice. This is the first genetic evidence showing that Smad3 inhibits mammary tumor formation in a mouse model. Our findings support the notion that Smad3 has important tumor suppressor function for breast cancer.
    Date: 2016-10
    Relation: Oncotarget. 2016 Oct;7(40):64878-64885.
    Link to: http://dx.doi.org/10.18632/oncotarget.11713
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000387281000026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84994121150
    Appears in Collections:[Isao Matsuura] Periodical Articles

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