國家衛生研究院 NHRI:Item 3990099045/9970
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    題名: Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice
    作者: Liu, Z;Kundu-Roy, T;Matsuura, I;Wang, G;Lin, Y;Lou, YR;Barnard, NJ;Wang, XF;Huang, MT;Suh, N;Liu, F
    貢獻者: Institute of Molecular and Genomic Medicine
    摘要: Previous studies based on cell culture and xenograft animal models suggest that Smad3 has tumor suppressor function for breast cancer during early stages of tumorigenesis. In this report, we show that DMBA (7,12-dimethylbenz[a]anthracene), a chemical carcinogen, induces mammary tumor formation at a significantly higher frequency in the Smad3 heterozygous mice than in the Smad3 wild type mice. This is the first genetic evidence showing that Smad3 inhibits mammary tumor formation in a mouse model. Our findings support the notion that Smad3 has important tumor suppressor function for breast cancer.
    日期: 2016-10
    關聯: Oncotarget. 2016 Oct;7(40):64878-64885.
    Link to: http://dx.doi.org/10.18632/oncotarget.11713
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000387281000026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84994121150
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