國家衛生研究院 NHRI:Item 3990099045/1211

NHRI > Institute of Biotechnology and Pharmaceutical Research > Chiung-Tong Chen > Periodical Articles > Item 3990099045/1211

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1211

Title:	Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents
Authors:	Li, WT;Hwang, DR;Chen, CP;Shen, CW;Huang, CL;Chen, TW;Lin, CH;Chang, YL;Chang, YY;Lo, YK;Tseng, HY;Lin, CC;Song, JS;Chen, HC;Chen, SJ;Wu, SH;Chen, CT
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	A series of N-heterocyclic indolyl glyoxylamides were synthesized and evaluated for in vitro and in vivo anticancer activities. They exhibited a broad spectrum of anticancer activity not only in murine leukemic cancer cells but also in human gastric, breast, and uterus cancer cells as well as their multidrug resistant sublines with a wide range of IC50 values. They also induced apoptosis and caused DNA fragmentation in human gastric cancer cells. Among the compounds studied, 7 showed the most potent activity of growth inhibition (IC50 = 17-1711 nM) in several human cancer cells. Given orally, compounds 7 and 13 dose-dependently prolonged the survival of animals inoculated with P388 leukemic cancer cells. N-Heterocyclic indolyl glyoxylamides may be useful as orally active chemotherapeutic agents against cancer and refractory cancerous diseases of multidrug resistance phenotype.
Keywords:	Chemistry, Medicinal
Date:	2003-04-24
Relation:	Journal of Medicinal Chemistry. 2003 Apr;46(9):1706-1715.
Link to:	http://dx.doi.org/10.1021/jm020471r
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000182488300015
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037464479
Appears in Collections:	[Chiung-Tong Chen] Periodical Articles [Shu-Jung Chen(1998-2001)] Periodical Articles [Hua-Chien Chen(1997-2001)] Periodical Articles

Files in This Item:

File	Description	Size	Format
000182488300015.pdf		199Kb	Adobe PDF	1136	View/Open

Loading...