國家衛生研究院 NHRI:Item 3990099045/1211
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    题名: Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents
    作者: Li, WT;Hwang, DR;Chen, CP;Shen, CW;Huang, CL;Chen, TW;Lin, CH;Chang, YL;Chang, YY;Lo, YK;Tseng, HY;Lin, CC;Song, JS;Chen, HC;Chen, SJ;Wu, SH;Chen, CT
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: A series of N-heterocyclic indolyl glyoxylamides were synthesized and evaluated for in vitro and in vivo anticancer activities. They exhibited a broad spectrum of anticancer activity not only in murine leukemic cancer cells but also in human gastric, breast, and uterus cancer cells as well as their multidrug resistant sublines with a wide range of IC50 values. They also induced apoptosis and caused DNA fragmentation in human gastric cancer cells. Among the compounds studied, 7 showed the most potent activity of growth inhibition (IC50 = 17-1711 nM) in several human cancer cells. Given orally, compounds 7 and 13 dose-dependently prolonged the survival of animals inoculated with P388 leukemic cancer cells. N-Heterocyclic indolyl glyoxylamides may be useful as orally active chemotherapeutic agents against cancer and refractory cancerous diseases of multidrug resistance phenotype.
    关键词: Chemistry, Medicinal
    日期: 2003-04-24
    關聯: Journal of Medicinal Chemistry. 2003 Apr;46(9):1706-1715.
    Link to: http://dx.doi.org/10.1021/jm020471r
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000182488300015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037464479
    显示于类别:[陳炯東] 期刊論文
    [陳淑貞(1998-2001)] 期刊論文
    [陳華鍵(1997-2001)] 期刊論文

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