國家衛生研究院 NHRI:Item 3990099045/1257

NHRI > Institute of Biotechnology and Pharmaceutical Research > Hsing-Pang Hsieh > Periodical Articles > Item 3990099045/1257

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1257

Title:	Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies
Authors:	Mahindroo, N;Wang, CC;Liao, CC;Huang, CF;Lu, IL;Lien, TW;Peng, YH;Huang, WJ;Lin, YT;Hsu, MC;Lin, CH;Tsai, CH;Hsu, JTA;Chen, X;Lyu, PC;Chao, YS;Wu, SY;Hsieh, HP
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	A series of novel indole-based PPAR agonists is described leading to discovery of 10k, a highly potent PPAR pan-agonist. The structural biology and molecular docking studies revealed that the distances between the acidic group and the linker, when a ligand was complexed with PPAR gamma protein, were important for the potent activity. The hydrophobic tail part of 10k makes intensive hydrophobic interaction with the PPAR gamma protein resulting in potent activity.
Keywords:	Chemistry, Medicinal
Date:	2006-02-09
Relation:	Journal of Medicinal Chemistry. 2006 Feb;49(3):1212-1216.
Link to:	http://dx.doi.org/10.1021/jm0510373
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000235826300040
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=32344437952
Appears in Collections:	[Hsing-Pang Hsieh] Periodical Articles [Su-Ying Wu] Periodical Articles [John Tsu-An Hsu] Periodical Articles [Yu-Sheng Chao(2002-2013)] Periodical Articles [Xin Chen(2002-2015)] Periodical Articles

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