國家衛生研究院 NHRI:Item 3990099045/1257
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    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/1257


    題名: Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies
    作者: Mahindroo, N;Wang, CC;Liao, CC;Huang, CF;Lu, IL;Lien, TW;Peng, YH;Huang, WJ;Lin, YT;Hsu, MC;Lin, CH;Tsai, CH;Hsu, JTA;Chen, X;Lyu, PC;Chao, YS;Wu, SY;Hsieh, HP
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: A series of novel indole-based PPAR agonists is described leading to discovery of 10k, a highly potent PPAR pan-agonist. The structural biology and molecular docking studies revealed that the distances between the acidic group and the linker, when a ligand was complexed with PPAR gamma protein, were important for the potent activity. The hydrophobic tail part of 10k makes intensive hydrophobic interaction with the PPAR gamma protein resulting in potent activity.
    關鍵詞: Chemistry, Medicinal
    日期: 2006-02-09
    關聯: Journal of Medicinal Chemistry. 2006 Feb;49(3):1212-1216.
    Link to: http://dx.doi.org/10.1021/jm0510373
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000235826300040
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=32344437952
    顯示於類別:[謝興邦] 期刊論文
    [伍素瑩] 期刊論文
    [徐祖安] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [陳新(2002-2015)] 期刊論文

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