國家衛生研究院 NHRI:Item 3990099045/12925

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12925

Title:	Investigation of cleansing and lubricating characteristics of a novel multifunctional contact lens care solution
Authors:	Fang, HW;Su, CY;Tsao, YF;Li, KY
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Purpose : The population of soft contact lens wearers is increasing, thus the issues of feeling comfortable and contact lens-induced clinical symptoms are concerned. After wearing a long period of time, adsorbed proteins may result in immune reactions if wearers do not clean the accumulated proteins thoroughly. We then investigated a multi-functional contact lens care solution we developed for the cleansing ability to remove lysozyme and for lubricating property. Methods : Two ionic contact lenses (Etafilcon-A and Ocufilcon-D) and two nonionic lenses (Polymacon, and Nelfilcon-A) were incubated in 1.9 mg/ml lysozyme solution for 24 hours, and lenses were cleaned with multi-functional contact lens care solution for 30 minute. Lysozyme deposited on the lens was extracted by sodium dodecyl sulfate, and enzyme-linked immunosorbent assay was conducted for measuring the amount of adsorbed lysozyme. For analyzing lubricating property of the care solution, contact lenses were sliding against a glass in saline, 1.9 mg/ml of lysozyme solution, or care solution containing 1.9 mg/ml lysozyme to analyze coefficient of friction (COF). All conditions were repeated 5 times for lysozyme deposition, and 4 times for friction testing. Results : When contact lenses were adsorbed in lysozyme and cleaned by the care solution, a significant amount of adsorbed lysozyme was removed from the lens despite of the materials of lenses (p<0.01). Lysozyme would increase COF of Polymacon (from 0.003 in PBS to 0.007 in lysozyme, p<0.05), but would not affect COF of Etalfilcon-A, Ocufilcon-D, and Nelfilcon-A lenses. When Polymacon lenses was sliding in both lysozyme and care solution, COF was decreased compared with it in lysozyme solution only (from 0.007 to 0.005). However,COF was not affected when Etafilcon-A, Ocufilcon-D, and Nelfilcon-A lenses were in lysozyme and care solution. Conclusions : Multi-functional contact lens care solution could effectively remove adsorbed lysozyme, suggesting good cleansing ability of the care solution. For lubricating property analysis, the result suggested that the care solution could reduce the high COF caused by lysozyme for Polymacon lenses. However, the care solution would not provide additional lubrication if COF was not affected by lysozyme.
Date:	2020-06
Relation:	Investigative Ophthalmology and Visual Science. 2020 Jun;61(7):Meeting Abstract 5015.
Link to:	https://iovs.arvojournals.org/article.aspx?articleid=2769435
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0146-0404&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000554528304248
Appears in Collections:	[Others] Conference Papers/Meeting Abstract

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