國家衛生研究院 NHRI:Item 3990099045/12925
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 855398      在线人数 : 1078
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12925


    题名: Investigation of cleansing and lubricating characteristics of a novel multifunctional contact lens care solution
    作者: Fang, HW;Su, CY;Tsao, YF;Li, KY
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Purpose : The population of soft contact lens wearers is increasing, thus the issues of feeling comfortable and contact lens-induced clinical symptoms are concerned. After wearing a long period of time, adsorbed proteins may result in immune reactions if wearers do not clean the accumulated proteins thoroughly. We then investigated a multi-functional contact lens care solution we developed for the cleansing ability to remove lysozyme and for lubricating property. Methods : Two ionic contact lenses (Etafilcon-A and Ocufilcon-D) and two nonionic lenses (Polymacon, and Nelfilcon-A) were incubated in 1.9 mg/ml lysozyme solution for 24 hours, and lenses were cleaned with multi-functional contact lens care solution for 30 minute. Lysozyme deposited on the lens was extracted by sodium dodecyl sulfate, and enzyme-linked immunosorbent assay was conducted for measuring the amount of adsorbed lysozyme. For analyzing lubricating property of the care solution, contact lenses were sliding against a glass in saline, 1.9 mg/ml of lysozyme solution, or care solution containing 1.9 mg/ml lysozyme to analyze coefficient of friction (COF). All conditions were repeated 5 times for lysozyme deposition, and 4 times for friction testing. Results : When contact lenses were adsorbed in lysozyme and cleaned by the care solution, a significant amount of adsorbed lysozyme was removed from the lens despite of the materials of lenses (p<0.01). Lysozyme would increase COF of Polymacon (from 0.003 in PBS to 0.007 in lysozyme, p<0.05), but would not affect COF of Etalfilcon-A, Ocufilcon-D, and Nelfilcon-A lenses. When Polymacon lenses was sliding in both lysozyme and care solution, COF was decreased compared with it in lysozyme solution only (from 0.007 to 0.005). However,COF was not affected when Etafilcon-A, Ocufilcon-D, and Nelfilcon-A lenses were in lysozyme and care solution. Conclusions : Multi-functional contact lens care solution could effectively remove adsorbed lysozyme, suggesting good cleansing ability of the care solution. For lubricating property analysis, the result suggested that the care solution could reduce the high COF caused by lysozyme for Polymacon lenses. However, the care solution would not provide additional lubrication if COF was not affected by lysozyme.
    日期: 2020-06
    關聯: Investigative Ophthalmology and Visual Science. 2020 Jun;61(7):Meeting Abstract 5015.
    Link to: https://iovs.arvojournals.org/article.aspx?articleid=2769435
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0146-0404&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000554528304248
    显示于类别:[其他] 會議論文/會議摘要

    文件中的档案:

    没有与此文件相关的档案.



    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈