國家衛生研究院 NHRI:Item 3990099045/15197
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    題名: A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects
    作者: Hsu, YT;Chen, SR;Chang, YC;Chang, HF;Yeh, TK;Chuang, JY;Loh, HH;Hsieh, HP;Ueng, SH;Yeh, SH
    貢獻者: Institute of Biotechnology and Pharmaceutical Research;NHRI Graduate Student Program
    摘要: The compelling demand of a consummate analgesic medication without addiction is rising due to the clinical mistreatment. Additionally, the series of severe untoward effects usually deterred the utilization while coping with serious pain. As a possible turning point, we revealed that compound 14 is a dual agonist of mu opioid receptor (MOR) and nociceptin-orphanin FQ opioid peptide (NOP) receptor in this study. More importantly, compound 14 achieves pain relieving at very small doses, meanwhile, reduces several unwanted side effects such as constipation, reward, tolerance and withdrawal effects. Here, we evaluated the antinociception and side effects of this novel compound from wild type and humanized mice to further develop a safer prescription analgesic drug.
    日期: 2023-10-05
    關聯: European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115608.
    Link to: http://dx.doi.org/10.1016/j.ejmech.2023.115608
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0223-5234&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001040117100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85164323105
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