| 2025-02 |
Development of BACE2-IN-1/tranylcypromine-based compounds to induce steroidogenesis-dependent neuroprotection |
Biomedicine and Pharmacotherapy. 2025 Feb;183:Article number 117851. |
 |
| 2024-11-21 |
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia |
Cell Chemical Biology. 2024 Nov 21;31(11):1885-1898.e10. |
|
| 2024-11 |
DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration |
Journal of Medicinal Chemistry. 2024 Nov 14;67(21):19777-19790. |
|
| 2024-05-01 |
Thiazolidinone compounds and use thereof |
EP3426246/2024-05-01 |
|
| 2023-10-05 |
A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects |
European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115608. |
|
| 2022-12-05 |
Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation |
European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728. |
|
| 2022-11-22 |
オピオイド受容体調節因子及びその使用 |
JP7181536/2022-11-22 |
|
| 2022-11 |
Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone |
Bioorganic Chemistry. 2022 Nov;128:Article number 105905. |
|
| 2022-08-30 |
チアゾリジノン化合物及びその使用 |
JP7132849/2022-08-30 |
|
| 2022-05-20 |
噻唑烷酮化合物及其用途 |
HK1258687/2022-05-20 |
|
| 2022-03-08 |
Opioid receptor modulators and use thereof |
CA2996281/2022-03-08 |
|
| 2022-02-16 |
티아졸리디논 화합물 및 그의 용도 |
KR10-2365673/2022-02-16 |
|
| 2022-01-19 |
噻唑烷酮化合物及其用途 |
J/005474/2022-01-19 |
|
| 2022-01-05 |
阿片受體調節劑及其用途 |
J/005174/2022-01-05 |
|
| 2021-09-28 |
噻唑烷酮化合物及其用途 |
CN108883099/2021-09-28 |
|
| 2021-09-24 |
阿片受體調節劑及其用途 |
HK1253294/2021-09-24 |
|
| 2021-07-22 |
Thiazolidinone compounds and use thereof |
AU2017229129/2021-07-22 |
|
| 2021-06-04 |
阿片受体调节剂及其用途 |
CN108369222/2021-06-04 |
|
| 2020-11-18 |
Opioid receptor modulators and use thereof |
EP3344997/2020-11-18 |
|
| 2020-10-08 |
Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery |
Scientific Reports. 2020 Oct 8;10:Article number 16771. |
|
| 2020-10 |
Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma |
Neuro-Oncology. 2020 Oct;22(10):1439-1451. |
|
| 2020-06 |
Morphine produces potent antinociception, sedation, and hypothermia in humanized mice expressing human mu opioid receptor splice variants |
Pain. 2020 Jun;161(6):1177-1190. |
|
| 2020-04-21 |
噻唑烷酮化合物及其用途 |
TWI691332/2020-04-21 |
|
| 2020-04-15 |
Betulinic acid-mediated tuning of PERK/CHOP signaling by Sp1 inhibition as a novel therapeutic strategy for glioblastoma |
Cancers. 2020 Apr 15;12(4):Article number 981. |
|
| 2020-04 |
BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine |
Neuropharmacology. 2020 Apr;166:Article number 107678. |
|
| 2020-04 |
Pharmacological studies of morphine in a novel humanized mu opioid receptor mouse model |
FASEB Journal. 2020 Apr;34(S1):Abstract number 02835. |
|
| 2020-03-24 |
Tetrahydroisoquinolines for use as MOR/NOP dual agonists |
US10597378/2020-03-24 |
|
| 2020-01-28 |
Thiazolidinone compounds and use thereof |
US10544113/2020-01-28 |
|
| 2019-04-01 |
The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone |
European Journal of Medicinal Chemistry. 2019 Apr 1;167:312-323. |
|
| 2019-02-20 |
Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice |
Scientific Reports. 2019 Feb 20;9:Article number 2405. |
|
| 2019-02-11 |
雜環化合物及其用途 |
TWI650313/2019-02-11 |
|
| 2018-08-04 |
Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress |
Redox Biology. 2018 Aug 4;19:74-80. |
|
| 2018-06-01 |
鴉片受體調節劑及其用途 |
TWI625120/2018-06-01 |
|
| 2017-11-28 |
Opioid receptor modulators and use thereof |
US9827228/2017-11-28 |
|
| 2017-05 |
1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A novel opioid receptor agonist with less accompanying gastrointestinal dysfunction than morphine |
Anesthesiology. 2017 May;126(5):952-966. |
|
| 2017-04 |
Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury |
Redox Biology. 2017 Apr;11:135-143. |
|
| 2017-03 |
Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers |
Biochimica Et Biophysica Acta(BBA)-Proteins and Proteomics. 2017 Mar;1865(3):336-343. |
|
| 2017-01 |
Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists |
European Journal of Medicinal Chemistry. 2017 Jan;126:202-217. |
|
| 2016-06 |
The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury |
Neuropharmacology. 2016 Jun;105:1-9. |
|
| 2015-10 |
Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening |
Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819. |
|
| 2014-12-01 |
Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling |
Nucleic Acids Research. 2014 Dec 1;42(21):13012-13025. |
|
| 2014-09 |
Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists |
Bioorganic and Medicinal Chemistry. 2014 Sep;22(17): 4694-4703. |
|
| 2012-06-29 |
58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway |
Journal of Biological Chemistry. 2012 Jun 29;287(27):22533-22548. |
|
| 2011-11 |
A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells |
Cell Death and Differentiation. 2011 Nov;18(11):1791-1804. |
|
| 2011-05 |
Selective inhibition of early-but not late-expressed HIF-1alpha is neuroprotective in rats after focal ischemic brain damage |
Brain Pathology. 2011 May;21(3):249-262. |
|
