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生技與藥物研究所
陳新(2002-2015)
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徐祖安
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李秀珠
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李靜琪
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林書玉
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洪明秀
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潘秀玲(2009-2013)
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王文傑
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王鴻俊
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石全(2014-2017)
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童俊維
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紀雅惠
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趙宇生(2002-2013)
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郭靜娟
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陳志豪
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顏婉菁
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許明珠(1997-2001)
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陳淑貞(1998-2001)
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陳華鍵(1997-2001)
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Probing for improved selectivity wi...
吡咯啶化合物
Pyrrolidine compounds
Pyrrolidine compounds
吡咯烷化合物
Pyrrolidine compounds
Pyrrolidine compounds
吲哚化合物
吡咯啉啶化合物
吲哚化合物
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Showing items 1-25 of 67. (3 Page(s) Totally)
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Date
Title
Relation
2016-03
Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: The impact of P1-variation
MedChemComm. 2016 Mar;7(3):433-438.
2014-06-09
EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog
PLoS ONE. 2014 Jun 9;9(6):Article number e92164.
2014-02
Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum
Journal of Biological Chemistry. 2014 Feb 14;289 (7):4444-4454.
2014-02
Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation
PLoS ONE. 2014 Feb 13;9(2):Article number e88772.
2013-08
Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum
Journal of Biological Chemistry. 2013 Aug;288(35):25330-25339.
2013-02-11
吡咯啶化合物
I385171/2013-02-11
2012-01-17
Pyrrolidine compounds
CA2559611/2012-01-17
2011-12-06
Pyrrolidine compounds
US8071787B2/2011-12-06
2011-11-04
Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9
FEBS Letters. 2011 Nov 4;585(21):3409-3414.
2011-09
Proline in transmembrane domain of type II protein DPP-IV governs Its translocation behavior through endoplasmic reticulum
Biochemistry. 2011 Sep;50(37):7909-7918.
2011-08
Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): Is DPP8-selectivity an attainable goal?
Journal of Medicinal Chemistry. 2011 Aug;54(16):5737-5746.
2011-06
Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate
Journal of Biochemistry. 2011 Jun;149(6):685-692.
2011-03
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
Journal of Cell Biology. 2011 Mar;192(5):825-838.
2010-12-01
吲哚化合物
ZL200480034988.8/2010-12-01
2010-12
Downregulation of signaling-active IGF-1 by dipeptidyl peptidase IV (DPP-IV)
International Journal of Biomedical Science. 2010 Dec;6(4):301-309.
2010-10-06
吡咯烷化合物
ZL200580009891.6/2010-10-06
2010-10
Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists
ChemMedChem. 2010 Oct;5(10):1707-1716.
2010-09
The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities
Protein Science. 2010 Sep;19(9):1627-1638.
2010-08
Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein
Journal of Medicinal Chemistry. 2010 Aug;53(18):6572-6583.
2010-06-15
(2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV
Bioorganic and Medicinal Chemistry Letters. 2010 Jun 15;20(12):3596-3600.
2010-03-30
Pyrrolidine compounds
US7687504B2/2010-03-30
2009-10
(1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases
Journal of the Chinese Chemical Society. 2009 Oct;56(5):1048-1055.
2009-09-03
Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis
FEBS Letters. 2009 Sep 3;583(17):2765-2771.
2009-07-15
Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor
Biochemical Pharmacology. 2009 Jul 15;78(2):203-210.
2009-06
Enzyme Activity and Immunohistochemical Localization of Dipeptidyl Peptidase 8 and 9 in Male Reproductive Tissues
Journal of Histochemistry and Cytochemistry. 2009 Jun;57(6):531-541.
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