| 2016-03 |
Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: The impact of P1-variation |
MedChemComm. 2016 Mar;7(3):433-438. |
 |
| 2014-06-09 |
EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog |
PLoS ONE. 2014 Jun 9;9(6):Article number e92164. |
|
| 2014-02 |
Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum |
Journal of Biological Chemistry. 2014 Feb 14;289 (7):4444-4454. |
|
| 2014-02 |
Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation |
PLoS ONE. 2014 Feb 13;9(2):Article number e88772. |
|
| 2013-08 |
Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum |
Journal of Biological Chemistry. 2013 Aug;288(35):25330-25339. |
|
| 2013-02-11 |
吡咯啶化合物 |
I385171/2013-02-11 |
|
| 2012-01-17 |
Pyrrolidine compounds |
CA2559611/2012-01-17 |
|
| 2011-12-06 |
Pyrrolidine compounds |
US8071787B2/2011-12-06 |
|
| 2011-11-04 |
Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9 |
FEBS Letters. 2011 Nov 4;585(21):3409-3414. |
|
| 2011-09 |
Proline in transmembrane domain of type II protein DPP-IV governs Its translocation behavior through endoplasmic reticulum |
Biochemistry. 2011 Sep;50(37):7909-7918. |
|
| 2011-08 |
Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): Is DPP8-selectivity an attainable goal? |
Journal of Medicinal Chemistry. 2011 Aug;54(16):5737-5746. |
|
| 2011-06 |
Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate |
Journal of Biochemistry. 2011 Jun;149(6):685-692. |
|
| 2011-03 |
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum |
Journal of Cell Biology. 2011 Mar;192(5):825-838. |
|
| 2010-12-01 |
吲哚化合物 |
ZL200480034988.8/2010-12-01 |
|
| 2010-12 |
Downregulation of signaling-active IGF-1 by dipeptidyl peptidase IV (DPP-IV) |
International Journal of Biomedical Science. 2010 Dec;6(4):301-309. |
|
| 2010-10-06 |
吡咯烷化合物 |
ZL200580009891.6/2010-10-06 |
|
| 2010-10 |
Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists |
ChemMedChem. 2010 Oct;5(10):1707-1716. |
|
| 2010-09 |
The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities |
Protein Science. 2010 Sep;19(9):1627-1638. |
|
| 2010-08 |
Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein |
Journal of Medicinal Chemistry. 2010 Aug;53(18):6572-6583. |
|
| 2010-06-15 |
(2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV |
Bioorganic and Medicinal Chemistry Letters. 2010 Jun 15;20(12):3596-3600. |
|
| 2010-03-30 |
Pyrrolidine compounds |
US7687504B2/2010-03-30 |
|
| 2009-10 |
(1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases |
Journal of the Chinese Chemical Society. 2009 Oct;56(5):1048-1055. |
|
| 2009-09-03 |
Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis |
FEBS Letters. 2009 Sep 3;583(17):2765-2771. |
|
| 2009-07-15 |
Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor |
Biochemical Pharmacology. 2009 Jul 15;78(2):203-210. |
|
| 2009-06 |
Enzyme Activity and Immunohistochemical Localization of Dipeptidyl Peptidase 8 and 9 in Male Reproductive Tissues |
Journal of Histochemistry and Cytochemistry. 2009 Jun;57(6):531-541. |
|
| 2009-06 |
A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.] |
European Journal of Medicinal Chemistry. 2009 Jun;44(6):2763-2763. |
|
| 2009-05-15 |
Biochemical properties and expression profile of human prolyl dipeptidase DPP9 |
Archives of Biochemistry and Biophysics. 2009 May 15;485(2):120-127. |
|
| 2009-04-23 |
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists |
Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2618-2622. |
|
| 2009-04-01 |
Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1908-1912. |
|
| 2009-03-15 |
Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors |
Bioorganic and Medicinal Chemistry. 2009 Mar 15;17(6):2388-2399. |
|
| 2009-01-22 |
Pyrrolidine compounds |
AU2005221678/2009-01-22 |
|
| 2009 |
Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme |
Antiviral Chemistry and Chemotherapy. 2009;19(4):151-156. |
|
| 2008-12-11 |
吲哚化合物 |
I304066/2008-12-11 |
|
| 2008-11-11 |
Indole compounds |
US7449478B2/2008-11-11 |
|
| 2008-08 |
A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors |
European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611. |
|
| 2008-07-21 |
吡咯啉啶化合物 |
I299039/2008-07-21 |
|
| 2008-07-15 |
Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: Identification of dipeptide derived leads |
Bioorganic and Medicinal Chemistry Letters. 2008 Jul;18(14):4154-4158. |
|
| 2008-07-15 |
Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2008 Jul;18(14):4159-4162. |
|
| 2008-07-01 |
Pyrrolidine compounds |
KR10-0844593/2008-07-01 |
|
| 2008-05-01 |
Purification and characterization of a dipeptidyl peptidase 9-like enzyme from bovine testes |
Frontiers in Bioscience. 2008 May 1;13(9):3558-3568. |
|
| 2008-05 |
Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana |
Phytotherapy Research. 2008 May;22(5):605-613. |
|
| 2008-04-15 |
Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus |
Biochemical Pharmacology. 2008 Apr;75(8):1601-1609. |
|
| 2008-04-06 |
COMP 266-Structure, function and inhibitors of prolyl dipeptidase DPP8 |
Abstracts of Papers - American Chemical Society. 2008 Apr 6;235:266-COMP. |
|
| 2007-11-15 |
Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates |
Journal of Medicinal Chemistry. 2007 Nov;50(23):5568-5570. |
|
| 2007-05 |
Dipeptidyl peptidase 8/9-like activity in human leukocytes |
Journal of Leukocyte Biology. 2007 May;81(5):1252-1257. |
|
| 2007-03-01 |
3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes |
Bioorganic and Medicinal Chemistry Letters. 2007 Mar;17(5):1274-1279. |
|
| 2006-12-15 |
Investigation of the dimer interface and substrate specificity of prolyl dipeptidase DPP8 |
Journal of Biological Chemistry. 2006 Dec;281(50):38653-38662. |
|
| 2006-12 |
Biochemical properties of recombinant prolyl dipeptidases DPP-IV and DPP8 |
Advances in Experimental Medicine and Biology. 2006 Dec;575:27-32. |
|
| 2006-10-19 |
Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists |
Journal of Medicinal Chemistry. 2006 Oct;49(21):6421-6424. |
|
| 2006-09 |
MEDI 416-3- 2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino -3-methyl-butyr amide analogs as DPP-IV inhibitors for the treatment of type-II diabetes |
Abstracts of Papers - American Chemical Society. 2006 Sep;232:MEDI 416. |
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