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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/2288
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| Title: | Detection of SARS-associated coronavirus in throat wash and saliva in early diagnosis |
| Authors: | Wang, WK;Chen, SY;Liu, IJ;Chen, YC;Chen, HL;Yang, CF;Chen, PJ;Yeh, SH;Kao, CL;Huang, LM;Hsueh, PR;Wang, JT;Sheng, WH;Fang, CT;Hung, CC;Hsieh, SM;Su, CP;Chiang, WC;Yang, JY;Lin, JH;Hsieh, SC;Hu, HP;Chiang, YP;Wang, JT;Yang, PC;Chang, SC |
| Contributors: | Division of Molecular and Genomic Medicine |
| Abstract: | The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is thought to be transmitted primarily through dispersal of droplets, but little is known about the load of SARS-CoV in oral droplets. We examined oral specimens, including throat wash and saliva, and found large amounts of SARS-CoV RNA in both throat wash (9.58 x 10(2) to 5.93 x 10(6) copies/mL) and saliva (7.08 X 10(3) to 6.38 x 10(8) copies/mL) from all specimens of 17 consecutive probable SARS case-patients, supporting the possibility of transmission through oral droplets. Immunofluorescence study showed replication of SARS-CoV in the cells derived from throat wash, demonstrating the possibility of developing a convenient antigen detection assay. This finding, with the high detection rate a median of 4 days after disease onset and before the development of lung lesions in four patients, suggests that throat wash and saliva should be included in sample collection guidelines for SARS diagnosis. |
| Keywords: | Immunology;Infectious Diseases |
| Date: | 2004-07 |
| Relation: | Emerging Infectious Diseases. 2004 Jul;10(7):1213-1219. |
| Link to: | http://www.cdc.gov/ncidod/EID/vol10no7/03-1113.htm |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1080-6040&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000222456800005 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84984539674 |
| Appears in Collections: | [葉秀慧(2001-2005)] 期刊論文
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| 000222456800005.pdf | | 146Kb | Adobe PDF | 860 | View/Open |
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