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Xanthine derivatives reveal an allo...
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2021-08-12
Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2)
Journal of Medicinal Chemistry. 2021 Aug 12;64(15):11288-11301.
2021-08-01
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity
Life Sciences. 2021 Aug 1;278:Article number 119574.
2021-01
Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease
European Journal of Medicinal Chemistry. 2021 Jan;209:Article number 112938.
2019-12
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia
Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150.
2019-05-28
Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform
Cancers. 2019 May 28;11(6):Article number 739.
2019-04-10
Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants
Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957.
2018-08-24
BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor
Cancer Science. 2018 Nov;109(11):3591-3601.
2016-10
BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT driven myeloid leukemia
Molecular Cancer Therapeutics. 2016 Oct;15(10):2323-2333.
2016-04-12
Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK)
Journal of Medicinal Chemistry. 2016 Apr 12;59(8):3906-3919.
2015-07
Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations
European Journal of Medicinal Chemistry. 2015 Jul;100:151-161.
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